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Literature summary for 1.14.20.1 extracted from
- Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication (1991), J. Biol. Chem., 266, 5087-5093.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Streptomyces clavuligerus |  |
| glutathione | reduced | Streptomyces clavuligerus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | required, without Fe2+, less than 2% of maximum activity | Streptomyces clavuligerus | |
| additional information | Fe2+ cannot be replaced by Mg2+, Mn2+, Ca2+, Co2+, Cu2+, Ni2+ or Zn2+ | Streptomyces clavuligerus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces clavuligerus | - |
also has activity of EC 1.14.11.26, deacetoxycephalosporin hydroxylase | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| penicillin N + 2-oxoglutarate + O2 | about 3%, compared to activity of EC 1.14.11.26, deacetoxycephalosporin hydroxylase | Streptomyces clavuligerus | deacetoxycephalosporin C + succinate + CO2 + H2O | - |
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