Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.44 extracted from

  • Cho, H.; Nakamura, M.; Clarke, S.
    Cloning, expression, and fatty acid regulation of the human DELTA-5 desaturase (1999), J. Biol. Chem., 274, 37335-37339.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Chinese hamster ovary cells Homo sapiens
expressed in Chinese hamster ovary cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
membrane
-
Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
arachidonoyl-CoA + ferricytochrome b5 + H2O
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
arachidonoyl-CoA + ferricytochrome b5 + H2O
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain most abundant in the brain Homo sapiens
-
heart most abundant in the heart Homo sapiens
-
kidney
-
Homo sapiens
-
liver most abundant in the liver Homo sapiens
-
lung
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Homo sapiens arachidonoyl-CoA + ferricytochrome b5 + H2O
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Rattus norvegicus arachidonoyl-CoA + ferricytochrome b5 + H2O
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Homo sapiens (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Rattus norvegicus (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + ferricytochrome b5 + H2O
-
?

Synonyms

Synonyms Comment Organism
D5D
-
Homo sapiens
D5D
-
Rattus norvegicus
delta-5 desaturase
-
Homo sapiens
delta-5 desaturase
-
Rattus norvegicus
FADS1
-
Homo sapiens
FADS1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Homo sapiens
cytochrome b5
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus when rats are fed a diet containing 10% safflower oil or menhaden fish oil, the level of hepatic mRNA for DELTA-5 desaturase is 25% of that found in the liver of rats fed a fat-free diet or a diet containing triolein down