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Literature summary for 1.14.19.41 extracted from

  • Martel, C.M.; Parker, J.E.; Bader, O.; Weig, M.; Gross, U.; Warrilow, A.G.; Kelly, D.E.; Kelly, S.L.
    A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B (2010), Antimicrob. Agents Chemother., 54, 3578-3583.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.41

Protein Variants

Protein Variants Comment Organism
additional information mutant CA108 is an erg11 erg5 double mutant harboring a single amino acid substitution (A114S) in sterol 14DELTA-demethylase (Erg11p) and sequence repetition (10 duplicated amino acids), which nullify C22 desaturase (Erg5p) function Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
clotrimazole
-
 Candida albicans
fluconazole
-
 Candida albicans
itraconazole
-
 Candida albicans
ketoconazole
-
 Candida albicans
voriconazole
-
 Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ergosta-5,7,24(28)-trien-3beta-ol + NADPH + H+ + O2 Candida albicans
-
 ergosta-5,7,22,24(28)-tetraen-3-beta-ol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ergosta-5,7,24(28)-trien-3beta-ol + NADPH + H+ + O2
-
 Candida albicans ergosta-5,7,22,24(28)-tetraen-3-beta-ol + NADP+ + H2O
-
 ?
ergosta-5,7-dienol + NADPH + H+ + O2
-
 Candida albicans ergosterol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
Erg5p
-
 Candida albicans
sterol C22 desaturase
-
 Candida albicans

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Candida albicans