Literature summary for 1.14.19.32 extracted from

Antony, B.; Soffan, A.; Jakse, J.; Alfaifi, S.; Sutanto, K.; Aldosari, S.; Aldawood, A.; Pain, A.
Genes involved in sex pheromone biosynthesis of Ephestia cautella, an important food storage pest, are determined by transcriptome sequencing (2015), BMC Genomics, 16, 532-557.

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Cloned(Commentary)

Cloned (Comment)	Organism
transcriptome analysis, overview	Cadra cautella

Organism

Organism	UniProt	Comment	Textmining
Cadra cautella	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+	DELTA14 and DELTA9 desaturation to generate Z9,E12-14:acyl	Cadra cautella	(14E)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
DELTA14-desaturase	-	Cadra cautella

General Information

General Information	Comment	Organism
evolution	origin and evolution of the DELTA14 desaturase, phylogenetic analysis and tree, detailed overview	Cadra cautella
metabolism	the enzyme is involved in the sex pheromone biosynthetic pathway. Two pathways exist, both initiate from C16:acyl-CoA, with one involving DELTA14 and DELTA9 desaturation to generate Z9,E12-14:acyl, and the other involving the chain shortening of C16:acyl-CoA to C14:acyl-CoA, followed by DELTA12 and DELTA9 desaturation to generate Z9,E12-14:acyl-CoA. Then, a final reduction and acetylation generates Z9,E12-14:OAc, overview. Desaturases introduce a double bond into the fatty acyl carbon chain, with strict regio- and stereo-selectivity	Cadra cautella
physiological function	the enzyme is involved in the synthesis of pheromone compound (Z,E)-9,12-tetradecadienyl acetate from pheromone precursor palmitoyl-CoA	Cadra cautella

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Release 2023.1 (January 2023)