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Literature summary for 1.14.19.3 extracted from

  • Das, U.N.
    A defect in the activity of DELTA6 and DELTA5 desaturases may be a factor in the initiation and progression of atherosclerosis (2007), Prostaglandins Leukot. Essent. Fatty Acids, 76, 251-268.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a biological target for the discovery and development of pharmaceuticals to treat atherosclerosis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genetic polymorphism of DELTA6 desaturase are naturally occuring in humans, a delivery of the gene for D6 desaturase to endothelial cells at atherosclerosis prone areas is expected to prevent/arrest the development of atherosclerosis despite the presence of hyperlipidemia, hypertension, diabetes mellitus, and at sites of shear stress of blood flow Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cholesterol
-
Homo sapiens
saturated fatty acids
-
Homo sapiens
trans-fats
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is essential for the formation of long-chain metabolites from dietary linoleic acid and alpha-linolenic acid, but shows a slow activity in humans. A defect in the activity of DELTA6 and DELTA5 desaturases decreases the formation of gamma-linolenic acid, dihomo-gamma-linoleic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid from dietary linoleic acid, and alpha-linolenic acid. This, in turn, leads to inadequate formation of prostaglandins E1 and I3, prostacyclin, lipoxins resolvins, neuroprotectin D1, NO, and nitrolipids that have anti-inflammatory and platelet anti-aggregatory actions, inhibit leukocyte activation, augment wound healing, and resolve inflammation and thus, leads to the initiation and progression of atheroslcerosis, metabolism of essential fatty acids, overview, enzyme activity is decreased in diabetes mellitus, hypertension, hyperlipidemia, and metabolic syndrome X ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene FADS1
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information wide tissue distribution Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is essential for the formation of long-chain metabolites from dietary linoleic acid and alpha-linolenic acid, but shows a slow activity in humans. A defect in the activity of DELTA6 and DELTA5 desaturases decreases the formation of gamma-linolenic acid, dihomo-gamma-linoleic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid from dietary linoleic acid, and alpha-linolenic acid. This, in turn, leads to inadequate formation of prostaglandins E1 and I3, prostacyclin, lipoxins resolvins, neuroprotectin D1, NO, and nitrolipids that have anti-inflammatory and platelet anti-aggregatory actions, inhibit leukocyte activation, augment wound healing, and resolve inflammation and thus, leads to the initiation and progression of atheroslcerosis, metabolism of essential fatty acids, overview, enzyme activity is decreased in diabetes mellitus, hypertension, hyperlipidemia, and metabolic syndrome X Homo sapiens ?
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?
additional information alpha-linoleic acid is converted to eicosapentaenoic acid by the enzyme, the enzyme is also active with linoleic, which is converted to gamma-linoleic acid, and oleic acid Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
DELTA6 desaturase
-
Homo sapiens
DELTA6-desaturase
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Homo sapiens