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Literature summary for 1.14.19.3 extracted from

  • Rodriguez, A.; Sarda, P.; Boulot, P.; Leger, C.L.; Descomps, B.
    Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series (1999), Lipids, 34, 23-30.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide n-3 DELTA6-desaturase is not inhibited, it increases, NEM specifically inhibits DELTA6-desaturase activity in the n-6 series, but not in the n-3-series Homo sapiens
N-ethylmaleimide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
microsome membrane Homo sapiens
-
-
microsome membrane Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
linoleic acid + AH2 + O2 Rattus norvegicus
-
gamma-linolenic acid + A + H2O
-
?
linoleic acid + AH2 + O2 Homo sapiens key enzyme localized in the endoplasmic reticulum gamma-linolenic acid + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fetus
-
Homo sapiens
-
fetus
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
liver fetal liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-linolenic acid + AH2 + O2
-
Homo sapiens stearidonic acid + A + 2 H2O
-
?
alpha-linolenic acid + AH2 + O2
-
Rattus norvegicus stearidonic acid + A + 2 H2O
-
?
linoleic acid + AH2 + O2
-
Rattus norvegicus gamma-linolenic acid + A + H2O
-
?
linoleic acid + AH2 + O2 key enzyme localized in the endoplasmic reticulum Homo sapiens gamma-linolenic acid + A + H2O
-
?
octadeca-9,12-dienoic acid + AH2 + O2
-
Homo sapiens gamma-linolenic acid + A + H2O
-
?
octadeca-9,12-dienoic acid + AH2 + O2
-
Rattus norvegicus gamma-linolenic acid + A + H2O
-
?