Literature summary for 1.14.19.29 extracted from

Libisch, B.; Michaelson, L.V.; Lewis, M.J.; Shewry, P.R.; Napier, J.A.
Chimeras of DELTA6-fatty acid and DELTA8-sphingolipid desaturases (2000), Biochem. Biophys. Res. Commun., 279, 779-785.

Search for more literature for 1.14.19.29

Cloned(Commentary)

Cloned (Comment)	Organism
expressed as chimera protein with DELTA6 fatty acid desaturase in Saccharomyces cervisiae	Borago officinalis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	Borago officinalis	39.8% conversion rate	(4R,8E)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	Borago officinalis	7.5% conversion rate	(4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Borago officinalis	Q9FR82	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	39.8% conversion rate	Borago officinalis	(4R,8E)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?
(4R)-4-hydroxysphinganine ceramide + ferrocytochrome b5 + O2 + H+	7.5% conversion rate	Borago officinalis	(4R,8Z)-4-hydroxysphing-8-enine ceramide + ferricytochrome b5 + H2O	-	?
additional information	no activity with palmitoleic acid, linoleic acid, and alpha-linolenic acid	Borago officinalis	?	-	?

Synonyms

Synonyms	Comment	Organism
DELTA8-sphingolipid desaturase	-	Borago officinalis

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	-	Borago officinalis

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Release 2023.1 (January 2023)