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Literature summary for 1.14.19.20 extracted from

  • Poklepovich, T.J.; Rinaldi, M.A.; Tomazic, M.L.; Favale, N.O.; Turkewitz, A.P.; Nudel, C.B.; Nusblat, A.D.
    The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae (2012), Steroids, 77, 1313-1320.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in an C-5(6) sterol desaturase erg3-deficient mutant of Saccharomyces cerevisia Tetrahymena thermophila

Inhibitors

Inhibitors Comment Organism Structure
cycloheximide
-
 Tetrahymena thermophila

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Tetrahymena thermophila 5783
-

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila C4PFX1
-
-
Tetrahymena thermophila CU428 C4PFX1
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila ergosterol + ferricytochrome b5 + H2O
-
 ?
5alpha-ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila CU428 ergosterol + ferricytochrome b5 + H2O
-
 ?
5alpha-ergosta-7,24-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila ergosta-5,7,24-trien-3beta-ol + ferricytochrome b5 + H2O
-
 ?
5alpha-ergosta-7,24-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila CU428 ergosta-5,7,24-trien-3beta-ol + ferricytochrome b5 + H2O
-
 ?
5alpha-ergosta-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila ergosta-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
 ?
5alpha-ergosta-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila CU428 ergosta-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
 ?
lanosterol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila ? + ferricytochrome b5 + H2O
-
 ?
lanosterol + ferrocytochrome b5 + O2 + H+
-
 Tetrahymena thermophila CU428 ? + ferricytochrome b5 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
C-5(6) sterol desaturase
-
 Tetrahymena thermophila
DES5A
-
 Tetrahymena thermophila
Des5Ap
-
 Tetrahymena thermophila
ERG3
-
 Tetrahymena thermophila

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Tetrahymena thermophila