Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate | - |
Plasmodium falciparum | |
methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate | - |
Plasmodium falciparum | |
methyl malvalate | - |
Plasmodium falciparum | |
methyl sterculate | inhibits the synthesis of oleic acid both with parasite lysates and infected erythrocytes, most likely by targeting SCD | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0566 | - |
stearoyl-CoA | in 0.1 M potassium phosphate buffer pH 7.2, at 37°C | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Plasmodium falciparum | 5783 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
114000 | - |
calculated from amino acid sequence | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8I0W9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
schizont | - |
Plasmodium falciparum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + NADPH + H+ + O2 | - |
Plasmodium falciparum | oleoyl-CoA + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD | - |
Plasmodium falciparum |
stearoyl-CoA desaturase | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Plasmodium falciparum | |
NADPH | SCD is mainly dependent on NADPH, no oleic acid is produced in the absence of NADPH | Plasmodium falciparum |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Plasmodium falciparum | calculated from amino acid sequence | - |
9.2 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.041 | - |
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C | Plasmodium falciparum | methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate | |
0.08 | - |
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C | Plasmodium falciparum | methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate | |
0.087 | - |
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C | Plasmodium falciparum | methyl sterculate | |
0.167 | - |
in 0.1 M potassium phosphate buffer pH 7.2, at 37°C | Plasmodium falciparum | methyl malvalate |
Organism | Comment | Expression |
---|---|---|
Plasmodium falciparum | there is a 53fold increase of SCD transcript expression level between 18 and 36 h during the late trophozoite stage | up |