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Literature summary for 1.14.19.1 extracted from
- The physiological role and control of mammalian fatty acyl-coenzyme A desaturases (1977), Biochem. Soc. Trans., 5, 811-818.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | stimulates activity in the microsomal fraction | Rattus norvegicus | |
| Insulin | causes 5fold increace of activity | Gallus gallus | |
| protein | non-substrate soluble cytosolic protein stimulates | Rattus norvegicus |  |
| stearoyl-CoA-binding protein | stimulates activity in the crude microsomal fraction | Rattus norvegicus | |
| thyroxine | - |
Gallus gallus | |
| triiodothyronine | - |
Gallus gallus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cycloheximide | - |
Gallus gallus | |
| ethyl linoleate | - |
Rattus norvegicus | |
| ethyl palmitate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Gallus gallus | 5783 | - |
| endoplasmic reticulum | bound | Rattus norvegicus | 5783 | - |
| microsome | membrane bound | Gallus gallus | - |
- |
| microsome | membrane bound | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | - |
Gallus gallus | |
| Fe2+ | contains one atom of non-heme iron per enzyme molecule, catalytic function | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53000 | - |
x * 53000 | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| stearate + AH2 + O2 | Rattus norvegicus | biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate | oleate + A + 2 H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
embryo | - |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | introduction of double bonds at fixed positions from the carboxyl group of the fatty acid. D-hydrogen atoms are removed during desaturation. Mixed-function oxidase, acting via hydroxy acid intermediates. Acetyl-CoA desaturase, carboxylase and fatty acid synthetase are all controlled together as a unit and influenced by dietary components | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heptadecanoate + AH2 + O2 | low activity | Rattus norvegicus | ? | - |
? | |
| nonadecanoate + AH2 + O2 | low activity | Rattus norvegicus | ? | - |
? | |
| stearate + AH2 + O2 | maximum activity | Rattus norvegicus | oleate + A + 2 H2O | - |
? | |
| stearate + AH2 + O2 | biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate | Rattus norvegicus | oleate + A + 2 H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Gallus gallus |
| ? | x * 53000 | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | flavin-containing NADH-cytochrome b5 reductase (EC 1.6.2.2.) | Rattus norvegicus | |
| heme | heme-containing cytochrome b5 | Rattus norvegicus | |
| NADH | - |
Gallus gallus | |
| NADH | - |
Rattus norvegicus | |
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