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Literature summary for 1.14.18.6 extracted from

  • Tani, M.; Kuge, O.
    Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids (2010), Mol. Microbiol., 78, 395-413.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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General Information

General Information Comment Organism
physiological function Deletion of hydroxylase scs7 causes synthetic lethality in combination deletion of phosphoinositide phosphatase SAC1. Overexpression of PSS1 encoding phosphatidylserine synthase complements the growth defects of scs7 deletion cells under SAC1-repressive conditions, and overexpression of Arf-GAP AGE1, which encodes aprotein related to membrane trafficking, also complements Saccharomyces cerevisiae