Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7L5A8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | FA2H is expressed in cultured human keratinocytes and human epidermis, with FA2H expression and fatty acid 2-hydroxylase activity increasing with differentiation | Homo sapiens | - |
keratinocyte | FA2H is expressed in cultured human keratinocytes and human epidermis, with FA2H expression and fatty acid 2-hydroxylase activity increasing with differentiation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | 2-hydroxylation of fatty acid by FA2H occurs prior to generation of ceramides/glucosylceramides. FA2H expression and 2-hydroxy-free fatty acid production increase early in keratinocyte differentiation, production of 2-hydroxyceramides/2-hydroxyglucosylceramides with longer chain amide-linked fatty acids (more than C24) increases later | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FA2H | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | differentiation-dependent up-regulation of ceramide synthesis and fatty acid elongation is accompanied by up-regulation of FA2H | up |
General Information | Comment | Organism |
---|---|---|
physiological function | FA2H-siRNA suppresses 2-hydroxylase activity and decreases 2-hydroxyceramide/2-hydroxyglucosylceramide levels. Keratinocytes transduced with FA2H-siRNA contain abnormal epidermal lamellar bodies and do not form the normal extracellular lamellar membranes required for the epidermal permeability barrier | Homo sapiens |