Application | Comment | Organism |
---|---|---|
medicine | silencing of sphingolipid fatty acyl 2-hydroxylase Fa2h turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Fa2H leads to an increased sensitivity to PM02734. Exogenous addition of the 2-hydroxylated fatty acid 2-hydroxy palmitic acid to different human cell lines increases their sensitivity to the cytotoxic compound | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in HCT116 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7L5A8 | - |
- |
Saccharomyces cerevisiae | Q03529 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
FA2H | - |
Homo sapiens |
SCS7 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | silencing of sphingolipid fatty acyl 2-hydroxylase Fa2h turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Fa2H leads to an increased sensitivity to PM02734 | Homo sapiens |
physiological function | silencing of sphingolipid fatty acyl 2-hydroxylase Scs7 turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Scs7 renders the cells hypersensitive to PM02734 | Saccharomyces cerevisiae |