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Literature summary for 1.14.18.6 extracted from
- Myelination in the absence of UDP-galactose: Ceramide galactosyl-transferase and fatty acid 2-hydroxylase (2011), BMC Neurosci., 12, 22.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q5MPP0 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | fatty acid 2-hydroxylase Fa2h/UDP-galactose:ceramide galactosyltransferase Cgt double-deficient mice lack sulfatide, GalCer, and in addition 2-hydroxylated fatty acid-galactosylceramide and sphingomyelin. Compared to Cgt-/- mice the amount of GlcCer in central nervous system myelin is strongly reduced in Fa2h-/-/Cgt-/- mice by more than 80%. This is accompanied by a significant increase in sphingomyelin, which is the predominant sphingolipid in Fa2h-/-/Cgt-/- mice. Compact myelin is formed in Fa2h-/-/Cgt-/- mice, and g-ratios of myelinated axons in the spinal cord of 4-week-old Fa2h-/-/Cgt-/- mice do not differ significantly from that of Cgt-/- mice, and there is no obvious phenotypic difference between Fa2h-/-/Cgt-/- and Cgt-/- mice | Mus musculus |
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Release 2023.1 (January 2023)
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