Literature summary for 1.14.18.2 extracted from

Omi, T.; Nakazawa, S.; Udagawa, C.; Tada, N.; Ochiai, K.; Chong, Y.H.; Kato, Y.; Mitsui, H.; Gin, A.; Oda, H.; Azakami, D.; Tamura, K.; Sako, T.; Inagaki, T.; Sakamoto, A.; Tsutsui, T.; Bonkobara, M.; Tsuchida, S.; Ikemoto, S.
Molecular characterization of the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene associated with the feline AB blood group system (2016), PLoS ONE, 11, e0165000 .

Search for more literature for 1.14.18.2

Cloned(Commentary)

Cloned (Comment)	Organism
gene CMAH, genotyping, genetic structure, and phylogenetic analysis. Haplotype inference, which is focused on non-synonymous single-nucleotide polymorphisms reveals that eight haplotypes carry one to four mutations in CMAH, and all cats with type B (n = 34) and AB (n = 2) blood carry two alleles derived from the mutated CMAH gene	Felis catus

Protein Variants

Protein Variants	Comment	Organism
D535N	naturally occuring mutation, genotyping, overview	Felis catus
E109D	naturally occuring mutation, genotyping, overview	Felis catus
G60V	naturally occuring mutation, genotyping, overview	Felis catus
I63V	naturally occuring mutation, genotyping, overview	Felis catus
P122S	naturally occuring mutation, genotyping, overview	Felis catus
R47C	naturally occuring mutation, genotyping, overview	Felis catus
V48M	naturally occuring mutation, genotyping, overview	Felis catus
Y90N	naturally occuring mutation, genotyping, overview	Felis catus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell membrane	-	Felis catus	-	-
cell surface	-	Felis catus	9986	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+	Felis catus	-	CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Felis catus	A6Y8N2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Felis catus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+	-	Felis catus	CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O	-	?

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	-	Felis catus

General Information

General Information	Comment	Organism
evolution	gene CMAH, genotyping, genetic structure, and phylogenetic analysis. Haplotype inference, which is focused on non-synonymous single-nucleotide polymorphisms reveals that eight haplotypes carry one to four mutations in CMAH, and all cats with type B (n = 34) and AB (n = 2) blood carry two alleles derived from the mutated CMAH gene	Felis catus
physiological function	the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene is associated with the feline AB blood group system, type A and type B antigens are Neu5Gc and Neu5Ac, respectively. Distribution of AB blood group antigens, CMAH gene structure, mutation, diplotypes, and haplotypes of the cat CMAH genes, overview. The feline AB blood group system consists of A and B antigens and contains blood group type A (type A), blood group type B (type B), and the rare blood group type AB (type AB). Type A erythrocytes express N-glycolylneuraminic acid (Neu5Gc) and type B erythrocytes express N-acetylneuraminic acid (Neu5Ac). The enzyme cytidinemonophosphate-N-acetylneuraminic acid hydroxylase synthesizes Neu5Ac to Neu5Gc. type AB erythrocytes have less Neu5Ac than type A erythrocytes and less Neu5Gc than type B erythrocytes	Felis catus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)