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Literature summary for 1.14.18.2 extracted from

  • Shaw, L.; Schauer, R.
    The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid (1988), Biol. Chem. Hoppe-Seyler, 369, 477-486.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + NADH + O2 Sus scrofa
-
 CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
submandibular gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + O2 less effectiove than NADH or NADPH Sus scrofa CMP-N-glycoloylneuraminate + ?
-
 ?
CMP-N-acetylneuraminate + ascorbic acid + O2 less effective than NADH or NADPH Sus scrofa CMP-N-glycoloylneuraminate + dehydroascorbate + H2O
-
 ?
CMP-N-acetylneuraminate + NADH + O2
-
 Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
CMP-N-acetylneuraminate + NADH + O2 NADPH and NADH are by far the most effective cofactors Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
CMP-N-acetylneuraminate + NADPH + O2 NADPH and NADH are by far the most effective cofactors Sus scrofa CMP-N-glycoloylneuraminate + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH NADPH and NADH are by far the most effective cofactors Sus scrofa
NADPH NADPH and NADH are by far the most effective cofactors Sus scrofa