Literature summary for 1.14.18.1 extracted from

Yi, W.; Cao, R.; Wen, H.; Yan, Q.; Zhou, B.; Wan, Y.; Ma, L.; Song, H.
Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 6490-6493.

Search for more literature for 1.14.18.1

Inhibitors

Inhibitors	Comment	Organism	Structure
4-formylphenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside	-	Agaricus bisporus
4-formylphenyl 2,3,4-tri-O-acetyl-beta-D-allopyranoside	-	Agaricus bisporus
4-formylphenyl 2,3,4-tri-O-benzyl-beta-D-ribopyranoside	-	Agaricus bisporus
4-formylphenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside	-	Agaricus bisporus
4-formylphenyl 2,3-O-(1-methylethylidene)-beta-D-allopyranoside	-	Agaricus bisporus
4-formylphenyl 4,6-O-(phenylmethylidene)-beta-D-gulopyranoside	-	Agaricus bisporus
4-formylphenyl 6-O-(dimethoxyphosphoryl)-beta-D-allopyranoside	-	Agaricus bisporus
4-formylphenyl 6-O-trityl-beta-D-allopyranoside	-	Agaricus bisporus
4-formylphenyl beta-D-allopyranoside	-	Agaricus bisporus
4-formylphenyl beta-D-glucopyranoside	-	Agaricus bisporus
4-formylphenyl beta-D-ribopyranoside	-	Agaricus bisporus
4-hydroxybenzaldehyde	-	Agaricus bisporus
4-methoxycinnamic acid	-	Agaricus bisporus
arbutin	-	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + O2	-	Agaricus bisporus	L-DOPA + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosinase	-	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.052	-	-	Agaricus bisporus	4-formylphenyl 4,6-O-(phenylmethylidene)-beta-D-gulopyranoside
0.28	-	-	Agaricus bisporus	4-formylphenyl beta-D-ribopyranoside
0.41	-	-	Agaricus bisporus	4-methoxycinnamic acid
0.43	-	-	Agaricus bisporus	4-formylphenyl 6-O-(dimethoxyphosphoryl)-beta-D-allopyranoside
0.62	-	-	Agaricus bisporus	4-formylphenyl 2,3-O-(1-methylethylidene)-beta-D-allopyranoside
0.94	-	-	Agaricus bisporus	4-formylphenyl beta-D-glucopyranoside
1.12	-	-	Agaricus bisporus	4-hydroxybenzaldehyde
2.54	-	-	Agaricus bisporus	4-formylphenyl beta-D-allopyranoside
3	-	-	Agaricus bisporus	4-formylphenyl 6-O-trityl-beta-D-allopyranoside
3	-	-	Agaricus bisporus	4-formylphenyl 2,3,4-tri-O-acetyl-beta-D-allopyranoside
3	-	-	Agaricus bisporus	4-formylphenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
3	-	-	Agaricus bisporus	4-formylphenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
3	-	-	Agaricus bisporus	4-formylphenyl 2,3,4-tri-O-benzyl-beta-D-ribopyranoside
8.4	-	-	Agaricus bisporus	arbutin

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Release 2023.1 (January 2023)