Literature summary for 1.14.18.1 extracted from

Magid, A.A.; Voutquenne-Nazabadioko, L.; Bontemps, G.; Litaudon, M.; Lavaud, C.
Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa (2008), Planta Med., 74, 55-60.

Search for more literature for 1.14.18.1

Inhibitors

Inhibitors	Comment	Organism	Structure
3-O-[2,6-di-O-alpha-L-rhamnopyranosyl-beta-D-galactopyranosyl]-quercetin	from Guioa villosa leaf extract	Agaricus bisporus
apigenin 4'-O-beta-D-glucopyranoside	from Guioa villosa leaf extract	Agaricus bisporus
betulin	from Guioa villosa leaf extract	Agaricus bisporus
chrysoeriol 4'-O-beta-D-glucopyranoside	from Guioa villosa leaf extract	Agaricus bisporus
crenulatoside A	from Guioa villosa leaf extract, inhibition at 5 mg/ml 23.7%	Agaricus bisporus
crenulatoside B	from Guioa villosa leaf extract	Agaricus bisporus
crenulatoside C	from Guioa villosa leaf extract	Agaricus bisporus
crenulatoside D	from Guioa villosa leaf extract	Agaricus bisporus
epicatechin-(4beta-8, 2beta-O-7)-epicatechin-(4beta-8)-epicatechin	from Guioa villosa leaf extract, inhibition at 5 mg/ml 34.6%	Agaricus bisporus
kojic acid	used as standard inhibitor for the tyrosinase	Agaricus bisporus
lupeol	from Guioa villosa leaf extract	Agaricus bisporus
luteolin 4'-O-beta-D-glucopyranoside	from Guioa villosa leaf extract, inhibition at 5 mg/ml 14%	Agaricus bisporus
mauritianin	from Guioa villosa leaf extract	Agaricus bisporus
soyacerebroside I	from Guioa villosa leaf extract, inhibition at 5 mg/ml 86.3%	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	2400 U/ml mushroom tyrosinase	Agaricus bisporus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-dopa + 1/2 O2	-	Agaricus bisporus	L-dopaquinone + H2O	-	?
L-tyrosine + O2 + AH2	-	Agaricus bisporus	L-dopa + H2O + A	-	?

Synonyms

Synonyms	Comment	Organism
tyrosinase	-	Agaricus bisporus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.8	-	assay at	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.68	-	-	Agaricus bisporus	kojic acid
1.13	-	-	Agaricus bisporus	soyacerebroside I
1.44	-	-	Agaricus bisporus	betulin
2.24	-	-	Agaricus bisporus	lupeol

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Release 2023.1 (January 2023)