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Literature summary for 1.14.18.1 extracted from

  • Setty, S.R.; Tenza, D.; Sviderskaya, E.V.; Bennett, D.C.; Raposo, G.; Marks, M.S.
    Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes (2008), Nature, 454, 1142-1146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.18.1

Localization

Localization Comment Organism GeneOntology No. Textmining
melanosome
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 Mus musculus 42470
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melanosome to catalyse melanin synthesis, tyrosinase is subsequently reloaded with copper within specialized organelles called melanosomes, immunofluorescence microscopy Mus musculus 42470
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additional information tryrosinase is present but inactive in BLOC-1-deficient melanocytes Mus musculus
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Metals/Ions

Metals/Ions Comment Organism Structure
copper copper transporter ATP7A localizes to melanosomes in wildtype melanocytes. Copper restores in vitro tyrosinase activity in melanosomes of BLOC-1-deficient melanocytes, immunofluorescence microscopy Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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 melanocyte cell lines
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Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopa + 1/2 O2
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 Mus musculus dopaquinone + H2O
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 ?

Synonyms

Synonyms Comment Organism
tyrosinase
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 Mus musculus