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Literature summary for 1.14.18.1 extracted from
- Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts (2007), J. Enzyme Inhib. Med. Chem., 22, 91-98.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arbutin | inhibitory effect on diphenolase activity of tyrosinase | Agaricus bisporus |  |
| crude ethanol phase | ECPE, inhibitory effect on diphenolase activity of tyrosinase | Agaricus bisporus | |
| hesperidin | inhibitory effect on tyrosinase diphenolase, from citrus peel crude extracts | Agaricus bisporus | |
| kojic acid | inhibitory effect on diphenolase activity of tyrosinase | Agaricus bisporus | |
| macroporus adsorption resin | FGRE, inhibitory effect on diphenolase activity of tyrosinase | Agaricus bisporus | |
| nobiletin | inhibitory effect on tyrosinase diphenolase, from citrus peel crude extracts | Agaricus bisporus | |
| petroleum ether | PCPE, inhibitory effect on diphenolase activity of tyrosinase | Agaricus bisporus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Agaricus bisporus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3900 | - |
- |
Agaricus bisporus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tyrosinase diphenolase | - |
Agaricus bisporus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.82 | - |
nobiletin | - |
Agaricus bisporus | |
| 9.16 | - |
hesperidin | - |
Agaricus bisporus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
IC50-value for petroleum ether: 8.09 mg/ml, IC50-value for crude ethanol phase (ECPE): 7.53 mg/ml, IC50-value for macroporus adsorption resin (FGRE): 4.80 mg/ml | Agaricus bisporus | additional information | |
| 0.0372 | - |
- |
Agaricus bisporus | kojic acid | |
| 1.49 | - |
- |
Agaricus bisporus | nobiletin | |
| 16.08 | - |
- |
Agaricus bisporus | hesperidin | |
| 27.31 | - |
- |
Agaricus bisporus | arbutin | |
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