Literature summary for 1.14.18.1 extracted from

Nesterov, A.; Zhao, J.; Minter, D.; Hertel, C.; Ma, W.; Abeysinghe, P.; Hong, M.; Jia, Q.
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane, a novel tyrosinase inhibitor with strong depigmenting effects (2008), Chem. Pharm. Bull., 56, 1292-1296.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane	tyrosinase inhibitor with strong depigmenting effects, found in the medicinal plant Dianella ensifolia. Synthetic and plant derived versions of the enzyme inhibit mushroom tyrosinase with similar potencies	Agaricus bisporus
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane	tyrosinase inhibitor with strong depigmenting effects, found in the medicinal plant Dianella ensifolia. 22times more potent than kojic acid	Mus musculus
2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol	plant-derived diarylpropane tyrosinase inhibitor	Agaricus bisporus
4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol	plant-derived diarylpropane tyrosinase inhibitor	Agaricus bisporus
kojic acid	commonly used tyrosinase inhibitor	Agaricus bisporus
kojic acid	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B16-F1 cell	mouse melanoma cell	Mus musculus	-
commercial preparation	-	Agaricus bisporus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-dopa + 1/2 O2	-	Mus musculus	L-dopaquinone + H2O	-	?
L-dopa + 1/2 O2	-	Agaricus bisporus	L-dopaquinone + H2O	-	?

Synonyms

Synonyms	Comment	Organism
dopa oxidase	DOPA oxidase activity of murine tyrosinase	Mus musculus
tyrosinase	-	Agaricus bisporus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0003	-	1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane	inhibition is competitive and reversible, about 15times more potent than kojic acid	Agaricus bisporus
0.0043	-	kojic acid	-	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00024	-	-	Agaricus bisporus	1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
0.001	-	-	Agaricus bisporus	2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol
0.012	-	-	Mus musculus	1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
0.024	-	-	Agaricus bisporus	4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol
0.273	-	-	Mus musculus	kojic acid

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Release 2023.1 (January 2023)