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Literature summary for 1.14.18.1 extracted from

  • Jimenez-Cervantes, C.; Garcia-Borron, J.C.; Valverde, P.; Solano, F.; Lozano, J.A.
    Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma (1993), Eur. J. Biochem., 217, 549-556.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
L-Dopa low-mobility enzyme form shows an absolute requirement of L-dopa for tyrosine hydroxylation in contrast to high-mobility enzyme form Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-Phenyl-2-thiourea
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
L-tyrosine high-mobility enzyme form Mus musculus
0.23
-
L-tyrosine low-mobility enzyme form Mus musculus
0.51
-
L-Dopa high-mobility enzyme form Mus musculus
1.9
-
L-Dopa low-mobility enzyme form Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
-
B16 melanoma cells
-
Mus musculus
-
high-mobility- and low-mobility tyrosinase
-

Purification (Commentary)

Purification (Comment) Organism
high-mobility tyrosinase form, ammonium sulfate, hydroxyapatite, gel filtration, low-mobility tyrosinase form, DEAE-Sephadex, partial purification Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell
-
Mus musculus
-