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Literature summary for 1.14.18.1 extracted from

  • Hearing, V.J.; Ekel, T.M.; Montague, P.M.; Hearing, E.D.; Nicholson, J.M.
    Mammalian tyrosinase: isolation by a simple new procedure and characterization of its steric requirements for cofactor activity (1978), Arch. Biochem. Biophys., 185, 407-418.
    View publication on PubMed
Search for more literature for 1.14.18.1

Activating Compound

Activating Compound Comment Organism Structure
L-Dopa and analogs, activation Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 N-acetyl-3,4-dihydroxyphenethylamine
-
 Mus musculus
0.016
-
 L-Dopa
-
 Mus musculus
0.02
-
 3,4-dihydroxyphenylethanol
-
 Mus musculus
0.022
-
 DL-dopa
-
 Mus musculus
0.024
-
 N-methyl-3,4-dihydroxyphenethylamine
-
 Mus musculus
0.026
-
 D-Dopa
-
 Mus musculus
0.046
-
 3,4-dihydroxyphenylalanine methyl ester
-
 Mus musculus
0.047
-
 3,4-Dihydroxyphenethylamine
-
 Mus musculus
0.094
-
 3,4,5-trihydroxyphenethylamine
-
 Mus musculus
0.102
-
 2,4,5-trihydroxyphenethylamine
-
 Mus musculus
0.145
-
 3,4-dihydroxyphenylserine
-
 Mus musculus
0.194
-
 3-(3,4-Dihydroxyphenyl)-2-methylalanine
-
 Mus musculus
0.23
-
 3,4-dihydroxyphenylglycol
-
 Mus musculus
0.305
-
 3,4,6-trihydroxyphenylalanine
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
preparative PAGE Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.032
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4,5-trihydroxyphenethylamine + O2
-
 Mus musculus ?
-
 ?
3,4,5-trihydroxyphenethylamine + O2
-
 Mus musculus ?
-
 r
3,4,6-trihydroxyphenylalanine + O2
-
 Mus musculus ?
-
 ?
3,4-dihydroxyphenethylamine + O2
-
 Mus musculus ?
-
 ?
3,4-dihydroxyphenylalanine methyl ester + O2
-
 Mus musculus ?
-
 ?
3,4-dihydroxyphenylethanol + O2
-
 Mus musculus 2-(3,4-dioxocyclohexa-1,5-dien-1-yl)ethanol + H2O
-
 r
3,4-dihydroxyphenylglycol + O2
-
 Mus musculus 2-(3,4-dioxocyclohexa-1,5-dien-1-yl)glycol + H2O
-
 r
3,4-dihydroxyphenylserine + O2
-
 Mus musculus ?
-
 ?
3-(3,4-dihydroxyphenyl)-2-methylalanine + O2
-
 Mus musculus ?
-
 ?
D-dopa + O2
-
 Mus musculus dopaquinone + H2O
-
 r
DL-DOPA + O2
-
 Mus musculus dopaquinone + H2O
-
 r
N-acetyl-3,4-dihydroxyphenethylamine + O2
-
 Mus musculus ?
-
 ?
N-methyl-3,4-dihydroxyphenethylamine + O2
-
 Mus musculus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0117
-
 tyrosine enzyme from malignant melanocytes Mus musculus
0.0217
-
 tyrosine enzyme from normal melanocytes Mus musculus