Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(acetyloxy)acetic acid | - |
Homo sapiens | |
([(2S)-2-[(2-aminopropanoyl)amino]-3-phenylpropanoyl]oxy)acetic acid | - |
Homo sapiens | |
([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanyl]oxy)acetic acid | - |
Homo sapiens | |
([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycyl]oxy)acetic acid | - |
Homo sapiens | |
([[(2S)-1-(2-aminopropanoyl)pyrrolidin-2-yl]carbonyl]oxy)acetic acid | - |
Homo sapiens | |
([[(2S)-1-[[(2-aminopropanoyl)amino]acetyl]pyrrolidin-2-yl]carbonyl]oxy)acetic acid | - |
Homo sapiens | |
([[(4-amino-6-methyl-3-oxoheptanoyl)amino]acetyl]oxy)acetic acid | - |
Homo sapiens | |
[[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid | - |
Homo sapiens | |
[[(2S)-2-([[(2-aminopropanoyl)amino]acetyl]amino)-3-phenylpropanoyl]oxy]acetic acid | - |
Homo sapiens | |
[[(2S)-2-amino-3-phenylpropanoyl]oxy]acetic acid | - |
Homo sapiens | |
[[(2S)-pyrrolidin-2-ylcarbonyl]oxy]acetic acid | - |
Homo sapiens | |
[[(acetylamino)acetyl]oxy]acetic acid | - |
Homo sapiens | |
[[N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanyl]oxy]acetic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.011 | - |
N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.016 | - |
N-acetyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.018 | - |
alanylglycylvalyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.035 | - |
alanylglycyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.2 | - |
alanyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.55 | - |
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.86 | - |
N-(4-amino-6-methyl-3-oxoheptanoyl)glycylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.88 | - |
L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
0.96 | - |
alanylglycylvalyl-L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
1.2 | - |
N-acetylglycylglycine | pH and temperature not specified in the publication | Homo sapiens | |
3 | - |
alanylglycyl-L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
4 | - |
alanyl-L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
6.5 | - |
L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
9.9 | - |
N-acetylglycine | pH and temperature not specified in the publication | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | required for activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidylglycine + ascorbate + O2 | Homo sapiens | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DMS-53 cell | - |
Homo sapiens | - |
small cell lung cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alanyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
alanyl-L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
alanylglycyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
alanylglycyl-L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
alanylglycylvalyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
alanylglycylvalyl-L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
additional information | the enzyme peptidylglycine alpha-amidating monooxygenase consists of two subunits: peptidylglycine alpha-hydroxylating monooxygenase that initiates formation of a radical at a substrate's C-terminal glycine alpha-carbon to then give an alpha-hydroxylated glycine derivative, and peptidylamidoglycolate lyase which catalyzes cleavage of this hydroxyglycine intermediate to give the amidated product with consequent release of glyoxylate | Homo sapiens | ? | - |
? | |
N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
N-(4-amino-6-methyl-3-oxoheptanoyl)glycylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
N-acetyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
N-acetylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
N-acetylglycylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | - |
Homo sapiens | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAM | - |
Homo sapiens |
peptidylglycine alpha-amidating monooxygenase | - |
Homo sapiens |
peptidylglycine alpha-hydroxylating monooxygenase | - |
Homo sapiens |
PHM | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.009 | - |
pH and temperature not specified in the publication | Homo sapiens | [[N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanyl]oxy]acetic acid | |
0.011 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid | |
0.038 | - |
pH and temperature not specified in the publication | Homo sapiens | ([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanyl]oxy)acetic acid | |
0.16 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-2-([[(2-aminopropanoyl)amino]acetyl]amino)-3-phenylpropanoyl]oxy]acetic acid | |
0.18 | - |
pH and temperature not specified in the publication | Homo sapiens | ([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycyl]oxy)acetic acid | |
0.2 | - |
pH and temperature not specified in the publication | Homo sapiens | ([[(4-amino-6-methyl-3-oxoheptanoyl)amino]acetyl]oxy)acetic acid | |
0.29 | - |
pH and temperature not specified in the publication | Homo sapiens | ([[(2S)-1-(2-aminopropanoyl)pyrrolidin-2-yl]carbonyl]oxy)acetic acid | |
0.37 | - |
pH and temperature not specified in the publication | Homo sapiens | ([(2S)-2-[(2-aminopropanoyl)amino]-3-phenylpropanoyl]oxy)acetic acid | |
0.5 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-pyrrolidin-2-ylcarbonyl]oxy]acetic acid | |
1.1 | - |
pH and temperature not specified in the publication | Homo sapiens | (acetyloxy)acetic acid | |
1.1 | - |
pH and temperature not specified in the publication | Homo sapiens | ([[(2S)-1-[[(2-aminopropanoyl)amino]acetyl]pyrrolidin-2-yl]carbonyl]oxy)acetic acid | |
1.6 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-2-amino-3-phenylpropanoyl]oxy]acetic acid | |
1.8 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(acetylamino)acetyl]oxy]acetic acid |