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Literature summary for 1.14.17.3 extracted from
- Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Reaction mechanism and role of the noncoupled nature of the active site (2004), J. Am. Chem. Soc., 126, 4991-5000.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | reaction thermodynamics | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | oxygen activation by the noncoupled binuclear copper site, analysis of structure and electron transfer mechanism, formation of a CuIIM-OOH reaction intermediate, thermodynamics | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O | detailed analysis of the reaction mechanism, role of noncoupled nature of the active site | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidylglycine + ascorbate + O2 | formation of a CuIIM-OOH intermediate, intramolecular electron transfer | Rattus norvegicus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptidylglycine alpha-hydroxylating monooxygenase | - |
Rattus norvegicus |
| PHM | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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