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Literature summary for 1.14.17.3 extracted from

  • Chikuma, T.; Kocha, T.; Hanaoka, K.; Kato, T.; Ishii, Y.; Tanaka, A.
    Characterization of peptidylglycine alpha-amidating monooxygenase in bovine hypothalamus (1994), Neurochem. Int., 25, 349-354.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
diethyldithiocarbamate copper chelator Bos taurus
additional information activity is not affected by pepstatin A, phenylmethylsulfonyl fluoride, and soybean trypsin inhibitor Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
dabsyl-Gly-Phe-Gly form 2 Bos taurus
0.143
-
dabsyl-Gly-Phe-Gly form 1 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ optimal activity at 0.016 mM Bos taurus
Cu2+ Cu2+ is absolutely required for optimal activity Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
49000
-
form 1, gel filtration Bos taurus
69000
-
form 2, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidylglycine + ascorbate + O2 Bos taurus
-
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus 2 forms, distinguishable by molecular weight Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-dimethylaminoazobenzene-4'-sulfonyl-Gly-L-Phe-Gly + ascorbate + O2
-
Bos taurus 4-dimethylaminoazobenzene-4'-sulfonyl-Gly-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
?
peptidylglycine + ascorbate + O2
-
Bos taurus peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?
peptidylglycine + ascorbate + O2 COOH-terminal glycine Bos taurus peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
2 optima: at pH 6.0 and at pH 7.5 Bos taurus
7.5
-
2 optima: at pH 6.0 and at pH 7.5 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ascorbate dependent on Bos taurus