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Literature summary for 1.14.17.3 extracted from

  • Mizuno, K.; Sakata, J.; Kojima, M.; Kangawa, K.; Matsuo, H.
    Peptide C-terminal alpha-amidating enzyme purified to homogeneity from Xenopus laevis skin (1986), Biochem. Biophys. Res. Commun., 137, 984-991.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dithiothreitol
-
Xenopus laevis
EDTA
-
Xenopus laevis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00035
-
acetyl-L-Tyr-L-Phe-Gly in presence of 0.25 mM ascorbate Xenopus laevis

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a copper protein Xenopus laevis
Cu2+ Cu2+ is absolutely required for optimal activity Xenopus laevis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
SDS-PAGE, gel filtration Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidylglycine + ascorbate + O2 Xenopus laevis
-
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Xenopus laevis

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
Xenopus laevis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-L-Tyr-L-Phe-Gly + ascorbate + O2
-
Xenopus laevis acetyl-L-Tyr-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
r
peptidylglycine + ascorbate + O2
-
Xenopus laevis peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?
peptidylglycine + ascorbate + O2 diverse synthetic substrates with C-terminal glycine Xenopus laevis peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?
peptidylglycine + ascorbate + O2 COOH-terminal glycine Xenopus laevis peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Subunits

Subunits Comment Organism
monomer 1 * 39000, SDS-PAGE Xenopus laevis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7
-
Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
ascorbate dependent on Xenopus laevis