Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyldithiocarbamate | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
D-Tyr-Val-Gly | PAM-B, with 1.25 mM ascorbate | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
secretory granule | - |
Bos taurus | 30141 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | a copper protein | Bos taurus | |
Cu2+ | Cu2+ is absolutely required for optimal activity | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38000 | - |
PAM-B, heterogeneous in size, gel filtration | Bos taurus |
48000 | - |
1 * 48000, PAM-A, heterogeneous in size, SDS-PAGE | Bos taurus |
54000 | - |
PAM-A, heterogeneous in size, gel filtration | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidylglycine + ascorbate + O2 | Bos taurus | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
2 forms: A and B | - |
Purification (Comment) | Organism |
---|---|
forms A and B differing in MW and charge | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pituitary gland | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.038 | - |
purified PAM-A | Bos taurus |
0.115 | - |
purified PAM-B | Bos taurus |
1.15 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Tyr-Val-Gly + ascorbate + O2 | - |
Bos taurus | D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | - |
Bos taurus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | COOH-terminal glycine | Bos taurus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 38000, PAM-B, heterogeneous in size, SDS-PAGE | Bos taurus |
monomer | 1 * 48000, PAM-A, heterogeneous in size, SDS-PAGE | Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
PAM-A | Bos taurus |
9 | 9.5 | PAM-B | Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 10 | pH 7.5: about 50% of activity maximum, pH 10: about 60% of activity maximum, PAM-B | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | dependent on | Bos taurus |