Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-Tyr-Val-Gly | at 2 mM 82% inhibition, at 0.1 mM 45% inhibition | Sus scrofa | |
Glyoxylate 2-pyridylhydrazone | - |
Sus scrofa | |
Glyoxylate 4-carboxyphenylhydrazone | - |
Sus scrofa | |
Glyoxylate benzylhydrazone | - |
Sus scrofa | |
glyoxylate phenylhydrazone | strongly | Sus scrofa | |
Glyoxylate phenylsemicarbazone | - |
Sus scrofa | |
Glyoxylate phenylthiosemicarbazone | - |
Sus scrofa | |
Glyoxylate semicarbazone | - |
Sus scrofa | |
glyoxylate thiosemicarbazone | - |
Sus scrofa | |
glyoxylate-N-hexyl-4-carbamoylphenylhydrazone | strongly | Sus scrofa | |
N-Carboxymethyl N'-phenylhydrazone | weak inhibition | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
gel fltration, SDS-PAGE | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidylglycine + ascorbate + O2 | Sus scrofa | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O | mechanism | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pituitary gland | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Tyr-Val-Gly + ascorbate + O2 | - |
Sus scrofa | D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
glyoxylic acid phenylhydrazone + ascorbate + O2 | competitive substrate, inhibitory | Sus scrofa | oxalate phenylhydrazide + dehydroascorbate + H2O | - |
? | |
additional information | substrates are also physiologically relevant peptides related to alpha-melanotropine | Sus scrofa | ? | - |
? | |
peptidylglycine + ascorbate + O2 | - |
Sus scrofa | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | COOH-terminal glycine | Sus scrofa | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 40000, SDS-PAGE | Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | dependent on | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
glyoxylate phenylhydrazone | - |
Sus scrofa | |
0.11 | - |
glyoxylate thiosemicarbazone | - |
Sus scrofa |