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Literature summary for 1.14.17.1 extracted from
- Dopamine beta-hydroxylase: activity and inhibition in the presence of beta-substituted phenethylamines (1982), Biochemistry, 21, 67-75.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-chlorophenethylamine | - |
Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
3,4-Dihydroxyphenethylamine | - |
Bos taurus | |
| 5.1 | - |
2-chlorophenethylamine | - |
Bos taurus | |
| 24 | - |
2-hydroxyphenethylamine | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenethylamine + ascorbate + O2 | Bos taurus | enzyme plays a key role in the biosynthetic interconversion of neurotransmitters | noradrenaline + dehydroascorbate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O | mechanism | Bos taurus | |
| dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O | stoichiometry | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-chlorophenethylamine + ascorbate + O2 | - |
Bos taurus | 2-amino-1-chloro-1-phenylethanol + dehydroascorbate + H2O | - |
? | |
| 2-hydroxyphenethylamine + ascorbate + O2 | - |
Bos taurus | 2-amino-1-phenylethane-1,1-diol + dehydroascorbate + H2O | - |
? | |
| 3,4-dihydroxyphenethylamine + ascorbate + O2 | - |
Bos taurus | noradrenaline + dehydroascorbate + H2O | norepinephrine | ? | |
| 3,4-dihydroxyphenethylamine + ascorbate + O2 | enzyme plays a key role in the biosynthetic interconversion of neurotransmitters | Bos taurus | noradrenaline + dehydroascorbate + H2O | - |
? | |
| additional information | enzyme with very broad substrate specificity | Bos taurus | ? | - |
? | |
| octopamine + ascorbate + O2 | - |
Bos taurus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
2-chlorophenethylamine | - |
Bos taurus | |
| 4.2 | - |
2-hydroxyphenethylamine | - |
Bos taurus | |
| 13 | - |
dopamine | - |
Bos taurus | |
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