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BRENDA support

Literature summary for 1.14.16.4 extracted from

  • Heydendael, W.; Jacobson, L.
    Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphe tryptophan hydroxylase gene expression (2009), Brain Res., 1288, 69-78.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
into pT vector and linearized with Nco I prior to antisense transcription with SP6 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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male C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information dorsal raphe Mus musculus
-

Synonyms

Synonyms Comment Organism
TPH2
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Mus musculus
tryptophan hydroxylase isoform2
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Mus musculus

Expression

Organism Comment Expression
Mus musculus imipramine increases dorsal raphe TPH2 gene expression in a glucocorticoid-dependent manner, increases are due to relief of inhibitory glucocorticoid signaling up