Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Acanthopanax senticosus, as aqueous extracts from fresh stem braks, increases the time to exhaustion by treadmill running and it suppressed the exercise-induced increase of 5-hydroxytryptamine synthesis and TPH expression. Acanthopanax senticosus is effective as caffeine for increasing the exhaustion time in treadmill running and for reducing the exercise-induced increase of 5-hydroxytryptamine synthesis and TPH expression in the dorsal raphe, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | TPH is involved in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, important neurotransmitters in the brain and involved in regulation of body temperature, blood pressure, endocrine activity, appetite, sexual behavior, movement, emesis, and pain, the enzyme activity plays a role in exercise-induced fatigue, overvieww | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | dorsal raphe nuclei | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH is involved in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, important neurotransmitters in the brain and involved in regulation of body temperature, blood pressure, endocrine activity, appetite, sexual behavior, movement, emesis, and pain, the enzyme activity plays a role in exercise-induced fatigue, overvieww | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH | - |
Rattus norvegicus |
tryptophan hydroxylase | - |
Rattus norvegicus |