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Literature summary for 1.14.16.4 extracted from

  • Reuter, M.; Ott, U.; Vaitl, D.; Hennig, J.
    Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene (2007), J. Cogn. Neurosci., 19, 401-408.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information gene TPH2, screening for naturally occuring polymorphisms associated with behavioural properties, e.g. attention, and intelligence, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH is rate-limiting in serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 TPH is rate-limiting in serotonin biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
-
Homo sapiens
tryptophan hydroxylase 2
-
Homo sapiens