Literature summary for 1.14.16.4 extracted from

Patel, P.D.; Bochar, D.A.; Turner, D.L.; Meng, F.; Mueller, H.M.; Pontrello, C.G.
Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif (2007), J. Biol. Chem., 282, 26717-26724.

Search for more literature for 1.14.16.4

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	TPH2 is upregulated by dominant-negative RE-1 silencer of transcription, minimum of 4.4fold relative to hypoxanthine-guanine phosphoribosyltransferase, overview	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
gene TPH2, DNA and amino acid sequence determination, analysis of the TPH2 promoter and bipartite NRSE motif, a transcription element in the TPH2 promoter, a bipartite variant interrupted by a 6-base insertion, that resembles the binding motif for RE-1 silencer of transcription, i.e. REST, also known as NRSF transcription factor, quantitative reverse transcription-PCR expression analysis, sequence comparisons	Rattus norvegicus
gene TPH2, DNA and amino acid sequence determination, identification of a transcription element in the TPH2 promoter, a bipartite variant interrupted by a 6-base insertion, that resembles the binding motif for RE-1 silencer of transcription, i.e. REST, also known as NRSF transcription factor, permutations of the motif reveal considerable flexibility in the juxtaposition of the two halves of bipartite NRSE, expressionin rat C6-glioma cells, quantitative reverse transcription-PCR expression analysis, sequence comparisons	Homo sapiens

Cloned (Comment)

Organism

gene TPH2, DNA and amino acid sequence determination, analysis of the TPH2 promoter and bipartite NRSE motif, a transcription element in the TPH2 promoter, a bipartite variant interrupted by a 6-base insertion, that resembles the binding motif for RE-1 silencer of transcription, i.e. REST, also known as NRSF transcription factor, quantitative reverse transcription-PCR expression analysis, sequence comparisons

Rattus norvegicus

gene TPH2, DNA and amino acid sequence determination, identification of a transcription element in the TPH2 promoter, a bipartite variant interrupted by a 6-base insertion, that resembles the binding motif for RE-1 silencer of transcription, i.e. REST, also known as NRSF transcription factor, permutations of the motif reveal considerable flexibility in the juxtaposition of the two halves of bipartite NRSE, expressionin rat C6-glioma cells, quantitative reverse transcription-PCR expression analysis, sequence comparisons

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
L-tryptophan + tetrahydrobiopterin + O2	Rattus norvegicus	TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	Homo sapiens	TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
additional information	Homo sapiens	TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview	?	-	?
additional information	Rattus norvegicus	TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IWU9	gene TPH2	-
Rattus norvegicus	Q8CGU9	gene TPH2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C6 glioma cell	-	Rattus norvegicus	-
glioma cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
L-tryptophan + tetrahydrobiopterin + O2	-	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	-	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
additional information	TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview	Homo sapiens	?	-	?
additional information	TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
TPH2	-	Homo sapiens
TPH2	-	Rattus norvegicus
tryptophan hydroxylase-2	-	Homo sapiens
tryptophan hydroxylase-2	-	Rattus norvegicus