Literature summary for 1.14.16.4 extracted from

Gizatullin, R.; Zaboli, G.; Joensson, E.G.; Asberg, M.; Leopardi, R.
The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression (2008), J. Affect. Disord., 107, 175-179.

Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment)	Organism
gene TPH2, DNA and amino acid sequence determination and analysis, genotyping	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	determination and analysis of TPH2 polymorphisms rs10748185, rs2129575, rs1386495, rs1386494, and rs7305115 in terms of genotype, allele, and haplotype-based associations, neither single marker nor haplotype-based analysis shows significant associations between TPH2 and MD, genotyping, in this particular group of stress-induced depression patients TPH1 appears to be more relevant to MD pathogenesis than TPH2, overview	Homo sapiens
additional information	genotyping, in a particular group of stress-induced depression patients isozyme TPH1 appears to be more relevant to MD pathogenesis than isozyme TPH2, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Homo sapiens	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	Homo sapiens	TPH2 is rate-limiting in serotonin, i.e. 5-hydroxytryptamine, biosynthesis, serotonin is involved in the pathophysiology of several psychiatric disorders including major depression, MD, overview	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P17752	TPH1; North European Caucasians, healthy persons and major depression patients, isozyme TPH1	-
Homo sapiens	Q8IWU9	North European Caucasians, healthy persons and major depression patients, isozyme TPH2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	TPH2 is rate-limiting in serotonin, i.e. 5-hydroxytryptamine, biosynthesis, serotonin is involved in the pathophysiology of several psychiatric disorders including major depression, MD, overview	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH-1	-	Homo sapiens
TPH-2	-	Homo sapiens
tryptophan hydroxylase 1	-	Homo sapiens
tryptophan hydroxylase 2	-	Homo sapiens

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Release 2023.1 (January 2023)