Cloned (Comment) | Organism |
---|---|
gene TPH2, DNA and amino acid sequence determination and analysis of wild-type and mutant genes, genotyping, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing, isolation and analysis of a serotonergic gene polymorphism related to brain affective processing is the tryptophan hydroxylase-2 gene TPH2, TPH2 rs4570625 genotyping, behavioural phenotypes, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | TPH2 is the rate-limiting enzyme during 5-hydroxytryptamine synthesis in the brain | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | Homo sapiens | additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing, serotonergic regulation of neural processing of affective stimuli with the striatum as a critical site where gene-gene regulation takes place, whole brain analysis for emotional word Stroop task, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | gene TPH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
striatum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the rate-limiting enzyme during 5-hydroxytryptamine synthesis in the brain | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing, serotonergic regulation of neural processing of affective stimuli with the striatum as a critical site where gene-gene regulation takes place, whole brain analysis for emotional word Stroop task, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Homo sapiens |