Literature summary for 1.14.16.4 extracted from

Zhang, X.; Beaulieu, J.M.; Gainetdinov, R.R.; Caron, M.G.
Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2 (2006), Cell. Mol. Life Sci., 63, 6-11.

Search for more literature for 1.14.16.4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	Gallus gallus	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	Drosophila melanogaster	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	Mus musculus	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	Rattus norvegicus	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	Danio rerio	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	Homo sapiens	over 300 single nucleotide polymorphisms have been identified and are associated with symptoms ranging from mild hyperphenylalaninemia to severe phenylketonuria	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-
Drosophila melanogaster	-	-	-
Gallus gallus	-	-	-
Homo sapiens	-	-	-
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
brain	-	Rattus norvegicus	-
neuron	expressed predominantly in serotonergic neurons	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Gallus gallus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Drosophila melanogaster	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Mus musculus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Danio rerio	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	over 300 single nucleotide polymorphisms have been identified and are associated with symptoms ranging from mild hyperphenylalaninemia to severe phenylketonuria	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH2	-	Gallus gallus
TPH2	-	Drosophila melanogaster
TPH2	-	Mus musculus
TPH2	-	Homo sapiens
TPH2	-	Rattus norvegicus
TPH2	-	Danio rerio
tryptophan hydroxylase 2	-	Gallus gallus
tryptophan hydroxylase 2	-	Drosophila melanogaster
tryptophan hydroxylase 2	-	Mus musculus
tryptophan hydroxylase 2	-	Homo sapiens
tryptophan hydroxylase 2	-	Rattus norvegicus
tryptophan hydroxylase 2	-	Danio rerio

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Release 2023.1 (January 2023)