Cloned (Comment) | Organism |
---|---|
TPH1, expression in Escherichia coli | Homo sapiens |
TPH2, expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH2, substrate inhibition | Homo sapiens | |
L-tryptophan | TPH2, substrate inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0106 | - |
L-tryptophan | TPH1 fusion protein with maltose-binding protein | Homo sapiens | |
0.0128 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH2 fusion protein with maltose-binding protein | Homo sapiens | |
0.0131 | - |
L-tryptophan | TPH2, in vitro transcription and translation product | Homo sapiens | |
0.0202 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH2 | Homo sapiens | |
0.0228 | - |
L-tryptophan | TPH1 | Homo sapiens | |
0.027 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH1 fusion protein with maltose-binding protein | Homo sapiens | |
0.039 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH1 | Homo sapiens | |
0.0403 | - |
L-tryptophan | TPH2 | Homo sapiens | |
0.0434 | - |
L-tryptophan | TPH2 fusion protein with maltose-binding protein | Homo sapiens | |
0.111 | - |
L-tryptophan | TPH1. in vitro transcription and translation product | Homo sapiens | |
0.146 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH1, in vitro transcription and translation product | Homo sapiens | |
0.281 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | TPH2, in vitro transcription and translation product | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58500 | - |
4 * 58500, TPH1 | Homo sapiens |
68500 | - |
4 * 68500, TPH2 | Homo sapiens |
234000 | - |
TPH1, gel filtration | Homo sapiens |
274000 | - |
TPH2, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydropteridine + O2 | Homo sapiens | rate-limiting step in biosynthesis of serotonin in brain | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | TPH1 is phosphorylated by cAMP-dependent protein kinase A | Homo sapiens |
phosphoprotein | TPH2 is phosphorylated by cAMP-dependent protein kinase A | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + ? | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | rate-limiting step in biosynthesis of serotonin in brain | Homo sapiens | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 58500, TPH1 | Homo sapiens |
tetramer | 4 * 68500, TPH2 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
TPH1 | - |
Homo sapiens |
TPH2 | - |
Homo sapiens |