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Literature summary for 1.14.16.4 extracted from

  • Naoi, M.; Maruyama, W.; Takahashi, T.; Ota, M.; Parvez, H.
    Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids (1994), Biochem. Pharmacol., 48, 207-211.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
D-Dopa noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin Mus musculus
dopamine noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin Mus musculus
L-Dopa noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin Mus musculus
L-tyrosine noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00873
-
L-tryptophan
-
Mus musculus
0.0344
-
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin biphasic kinetic, low Km value Mus musculus
0.796
-
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin biphasic kinetic, high Km value Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
mastocytoma cell line P-815
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.007
-
dopamine vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with high affinity Mus musculus
0.0162
-
L-tyrosine vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with high affinity Mus musculus
0.017
-
L-Dopa vs. L-tryptophan Mus musculus
0.0185
-
L-tyrosine vs. L-tryptophan Mus musculus
0.0393
-
dopamine vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with low affinity Mus musculus
0.0761
-
D-Dopa vs. L-tryptophan Mus musculus
0.0803
-
L-Dopa vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with high affinity Mus musculus
0.0887
-
L-Dopa vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with low affinity Mus musculus
0.0943
-
dopamine vs. L-tryptophan Mus musculus
0.202
-
D-Dopa vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with low affinity Mus musculus
0.306
-
L-tyrosine vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with low affinity Mus musculus
0.609
-
D-Dopa vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, component with high affinity Mus musculus