Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.4 extracted from

  • Ichiyama, A.; Nakamura, S.; Nishizuka, Y.; Hayaishi, O.
    Enzymic studies on the biosynthesis of serotonin in mammalian brain (1970), J. Biol. Chem., 245, 1699-1709.
    View publication on PubMed
Search for more literature for 1.14.16.4

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 L-tryptophan enzyme from crude mitochondrial fraction Cavia porcellus
0.006
-
 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine soluble enzyme from brain Cavia porcellus
0.3
-
 L-tryptophan soluble enzyme from brain Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
particle-bound
-
 Cavia porcellus
-
-
particle-bound
-
 Bos taurus
-
-
soluble
-
 Cavia porcellus
-
-
soluble
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydropteridine + O2 Cavia porcellus enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?
L-tryptophan + tetrahydropteridine + O2 Bos taurus enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cavia porcellus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Cavia porcellus
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain serotonergic neurons Cavia porcellus
-
brain serotonergic neurons Bos taurus
-

Storage Stability

Storage Stability Organism
-20°C, 2 months, 40% loss of activity Cavia porcellus
-20°C, 2 months, 40% loss of activity Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine + O2
-
 Cavia porcellus ?
-
 r
L-tryptophan + tetrahydropteridine + O2
-
 Cavia porcellus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?
L-tryptophan + tetrahydropteridine + O2
-
 Bos taurus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?
L-tryptophan + tetrahydropteridine + O2 enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin Cavia porcellus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?
L-tryptophan + tetrahydropteridine + O2 enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin Bos taurus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5 soluble enzyme from brain Cavia porcellus