Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | molecules phosphorylated at their Ser31 and Ser40 are localized predominantly in the cytoplasm of PC-12D cells | Rattus norvegicus | 5737 | - |
nucleus | molecules phosphorylated at Ser19 are found mainly in the nucleus | Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | enzyme molecules phosphorylated at their Ser31 and Ser40 are localized predominantly in the cytoplasm of PC12D cells. However, those molecules phosphorylated at Ser19 are found mainly in the nucleus, whereas they are negligible in the cytoplasm. The phosphorylation of the N-terminal portion regulates the degradation of this enzyme by the ubiquitin-proteasome pathway | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12D cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis | Rattus norvegicus |