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Literature summary for 1.14.16.2 extracted from

  • Nakashima, A.; Mori, K.; Kaneko, Y.S.; Hayashi, N.; Nagatsu, T.; Ota, A.
    Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme (2011), Biochem. Biophys. Res. Commun., 407, 343-347.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm molecules phosphorylated at their Ser31 and Ser40 are localized predominantly in the cytoplasm of PC-12D cells Rattus norvegicus 5737
-
nucleus molecules phosphorylated at Ser19 are found mainly in the nucleus Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus
-
3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein enzyme molecules phosphorylated at their Ser31 and Ser40 are localized predominantly in the cytoplasm of PC12D cells. However, those molecules phosphorylated at Ser19 are found mainly in the nucleus, whereas they are negligible in the cytoplasm. The phosphorylation of the N-terminal portion regulates the degradation of this enzyme by the ubiquitin-proteasome pathway Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
PC-12D cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis Rattus norvegicus