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Literature summary for 1.14.16.2 extracted from

  • Terpstra, B.T.; Collier, T.J.; Marchionini, D.M.; Levine, N.D.; Paumier, K.L.; Sortwell, C.E.
    Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons (2007), J. Neurosci. Methods, 166, 13-19.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus key enzyme in dopamine biosynthesis, the enzyme is involved in the survival of grafted embryonic dopamine neurons after transplantation, overview 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male E14 Fisher 344 rats
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Source Tissue

Source Tissue Comment Organism Textmining
corpus striatum
-
 Rattus norvegicus
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midbrain
-
 Rattus norvegicus
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neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
L-tyrosine + tetrahydrobiopterin + O2 key enzyme in dopamine biosynthesis, the enzyme is involved in the survival of grafted embryonic dopamine neurons after transplantation, overview Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
 Rattus norvegicus