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Literature summary for 1.14.16.2 extracted from
- Long-term modulation of tyrosine hydroxylase activity and expression by endothelin-1 and -3 in the rat anterior and posterior hypothalamus (2008), Am. J. Physiol. Regul. Integr. Comp. Physiol., 294, R905-R914.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| endothelin-1 | effects of long-term modulation at different concentrations, overview | Rattus norvegicus |  |
| endothelin-2 | effects of long-term modulation at different concentrations, overview | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| endothelin-1 | effects of long-term modulation at different concentrations, overview | Rattus norvegicus | |
| endothelin-2 | effects of long-term modulation at different concentrations, overview | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | enzyme ativity regulation by endothelins is mediated by the NO pathway, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hypothalamus | anterior and posterior | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 6-methyl-tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | enzyme ativity regulation by endothelins is mediated by the NO pathway, overview | Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tyrosine hydroxylase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 6-methyl-tetrahydrobiopterin | - |
Rattus norvegicus | |
| tetrahydrobiopterin | - |
Rattus norvegicus | |
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