Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1-methyl-3-isobutylxanthine | 1.5 mM | Heteropneustes fossilis | |
adenosine 3',5' cyclic monophosphate | 1 mM | Heteropneustes fossilis | |
estradiol-17beta | activating at concetration below 0.5 mM | Heteropneustes fossilis | |
theophylline | 1.5 mM | Heteropneustes fossilis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estradiol-17beta | inhibiting at concetration above 0.5 mM. adenosine 3',5' cyclic monophosphate enhances the inhibition at high estradiol-17beta concentrations | Heteropneustes fossilis | |
additional information | inhibition of cAMP-protein kinase A and protein kinase C in crude extracts significantly reduces tyrosine hydroxylase activity | Heteropneustes fossilis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 10 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00015 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 1 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.0002 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 10 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.0002 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 1 nM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00022 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 1 nM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00024 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 1 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00024 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 1 fM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00026 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 1 fM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00034 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00035 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00045 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 0.01 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00048 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 0.01 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00054 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | telencephalon extract, 1 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis | |
0.00058 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | hypothalamus extract, 1 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C | Heteropneustes fossilis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Heteropneustes fossilis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Heteropneustes fossilis | - |
telencephalon | - |
Heteropneustes fossilis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine + O2 | - |
Heteropneustes fossilis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TH | - |
Heteropneustes fossilis |
tyrosine hydroxylase | - |
Heteropneustes fossilis |