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Literature summary for 1.14.16.2 extracted from

  • Joy, K.P.; Chaube, R.
    Catecholaminergic control of LH secretion: E2 modulation of tyrosine hydroxylase activity in female catfish Heteropneustes fossilis (2004), Fish Physiol. Biochem., 28, 33-35.
No PubMed abstract available
Search for more literature for 1.14.16.2

Activating Compound

Activating Compound Comment Organism Structure
estradiol-17beta biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit Heteropneustes fossilis

Inhibitors

Inhibitors Comment Organism Structure
estradiol-17beta biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit Heteropneustes fossilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 L-tyrosine 30°C Heteropneustes fossilis
0.34
-
 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine 30°C Heteropneustes fossilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Heteropneustes fossilis circulating titer of estradiol-17 beta can act differentially on the enzyme to alter catecholamineergic activity. Estradiol-17 beta may participate in the acute regulation of the enzyme by interacting with the cAMP signaling pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Heteropneustes fossilis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
 Heteropneustes fossilis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine + O2
-
 Heteropneustes fossilis 3,4-dihydroxy-L-phenylalanine + ?
-
 ?
additional information circulating titer of estradiol-17 beta can act differentially on the enzyme to alter catecholamineergic activity. Estradiol-17 beta may participate in the acute regulation of the enzyme by interacting with the cAMP signaling pathway Heteropneustes fossilis ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine
-
 Heteropneustes fossilis