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Literature summary for 1.14.16.2 extracted from

  • Martinez, A.; Abeygunawardana, C.; Haavik, J.; Flatmark, T.; Mildvan, A.S.
    Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by 1H-NMR (1993), Adv. Exp. Med. Biol., 338, 77-80.
    View publication on PubMed
Search for more literature for 1.14.16.2

Inhibitors

Inhibitors Comment Organism Structure
Co2+ competitive against Fe2+ Homo sapiens
L-erythro-7,8-dihydrobiopterin competitive against tetrahydropterin Homo sapiens
Ni2+ competitive against Fe2+ Homo sapiens
Zn2+ competitive against Fe2+ Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 tyrosine
-
 Homo sapiens
0.06 0.1 6-Methyl-5,6,7,8-tetrahydropterin
-
 Homo sapiens
0.085
-
 phenylalanine
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Iron incorporation of stoichiometric amounts of Fe2+ leads to 40fold increase in activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens
-
 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 4 isoforms hTH1, hTH2, hTH3, hTH4
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine H-NMR analysis of conformation of the complex between phenylalanine, 6-methyltetrahydropterin and isoform hTH1 Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + tetrahydropteridine + 2 O2
-
 Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydropteridine + 2 H2O
-
 ?
L-phenylalanine + tetrahydropteridine + O2
-
 Homo sapiens L-tyrosine + dihydropteridine + H2O
-
 ?
L-tyrosine + 6-methyltetrahydropterin + O2 higher activity than with tetrahydropterin Homo sapiens ?
-
 ?
L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?
L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?

Synonyms

Synonyms Comment Organism
TH
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.07
-
 L-erythro-7,8-dihydrobiopterin
-
 Homo sapiens