Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity of recombinant enzyme is activated 1.5fold by exposure to pH 8.5-9.0 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C237D | approx. 3fold higher activity than wild-type | Homo sapiens |
C237S | approx. 2fold higher activity than wild-type | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | 0.04 | tetrahydrobiopterin | recombinant wild-type, C237S and C237D mutant enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9.5 | recombinant enzyme, 25% loss of activity at pH 5.5, 15% loss of activity at pH 7.0-8.0 | Homo sapiens |