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Literature summary for 1.14.16.1 extracted from
- Phenylalanine 4-monooxygenase from bovine liver (1987), Methods Enzymol., 142, 35-44.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bathophenanthroline disulfonate | 0.025 mM, 50% inhibition | Bos taurus |  |
| additional information | not inhibited by bathocuproine | Bos taurus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | less than 0.01 copper atoms per 50000 Da subunit | Bos taurus | |
| Iron | iron-protein | Bos taurus | |
| Iron | 1.5-3.0 iron atoms per 50000 Da subunit | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51000 | - |
x * 51000, SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | enzyme is phosphorylated in vitro by the catalytic subunit of cAMP-dependent protein kinase | Bos taurus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| polyethylene glycol, Phenyl-Sepharose, DEAE-Sepharose | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.09 | - |
cofactor 6,7-dimethyltetrahydropterin | Bos taurus |
| 0.17 | - |
cofactor 6-methyltetrahydropterin | Bos taurus |
| 0.23 | - |
cofactor tetrahydrobiopterin | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine + tetrahydrobiopterin + O2 | additional electron donors: 6-methylpterin, 6,7-dimethyltetrahydropterin | Bos taurus | L-tyrosine + dihydrobiopterin + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 51000, SDS-PAGE | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | artificial cofactors: 6-methyltetrahydropterin, 6,7-dimethyltetrahydropterin | Bos taurus | |
| tetrahydrobiopterin | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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