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Literature summary for 1.14.15.6 extracted from

  • Warita, K.; Mitsuhashi, T.; Sugawara, T.; Tabuchi, Y.; Tanida, T.; Wang, Z.; Matsumoto, Y.; Yokoyama, T.; Kitagawa, H.; Miki, T.; Takeuchi, Y.; Hoshi, N.
    Direct effects of diethylstilbestrol on the gene expression of the cholesterol side-chain cleavage enzyme (P450scc) in testicular Leydig cells (2010), Life Sci., 87, 281-285.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene p450scc, semi-/quantitative RT-PCR expression analysis, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Mus musculus 5743
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
gene p450scc
-

Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell
-
Mus musculus
-
testis
-
Mus musculus
-
TTE1 cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
cholesterol side-chain cleavage enzyme
-
Mus musculus
CYP11A1
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Mus musculus
cytochrome P450-mediated cholesterol side-chain cleavage enzyme
-
Mus musculus
P450scc
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus P450scc expression is reduced in Leydig cells treated with synthetic hormone diethylstilbestrol and natural hormone 17beta-estradiol. Diethylstilbestrol causes histone deacetylation in the P450scc promoter region, while 17beta-estradiol does not down
Mus musculus induction of P450scc mRNA expression by 8-Br-cAMP up