Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17,20-dihydroxyvitamin D2 | competitive inhibitor | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0091 | - |
cholesterol | in 0.45% cyclodextrin | Bos taurus | |
0.012 | - |
20-hydroxyvitamin D2 | in 0.45% cyclodextrin | Bos taurus | |
0.0175 | - |
vitamin D2 | in 0.45% cyclodextrin | Bos taurus | |
0.0181 | - |
17,20-dihydroxyvitamin D2 | in 0.45% cyclodextrin | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Bos taurus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17,20-dihydroxyvitamin D2 + reduced adrenodoxin + O2 | is slowly metabolized | Bos taurus | 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + O2 | - |
? | |
20-hydroxyvitamin D2 + reduced adrenodoxin + O2 | is a better substrate than vitamin D2 itself | Bos taurus | 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + O2 | - |
? | |
cholesterol + reduced adrenodoxin + O2 | - |
Bos taurus | pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O | - |
? | |
vitamin D2 + reduced adrenodoxin + O2 | P450scc catalyzes three sequential hydroxylations of D2 producing 20-hydroxyvitamin D2, 17,20-dihydroxyvitamin D2, and 17,20,24-trihydroxyvitamin D2, which dissociate from the active site of P450scc and accumulate in the reaction mixture | Bos taurus | 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP11A1 | - |
Bos taurus |
cytochrome P450scc | - |
Bos taurus |
P450scc | - |
Bos taurus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | in 0.45% cyclodextrin, the kcat of cholesterol is 6.1 mol/min/mol P450scc, the kcat of vitamin D2 is 2.28 mol/min/mol P450scc, the kcat of 20-hydroxyvitamin D2 is 2.47 mol/min/mol P450scc and the kcat of 17,20-dihydroxyvitamin D2 is 0.33 mol/min/mol P450scc. In phosphatidylcholine vesicles, the kcat of cholesterol is 46 mol/min/mol P450scc, the kcat of vitamin D2 is 5.62 mol/min/mol P450scc, the kcat of 20-hydroxyvitamin D2 is 1.99 mol/min/mol P450scc and the kcat of 17,20-dihydroxyvitamin D2 is 0.21 mol/min/mol P450scc | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adrenodoxin | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
metabolism | vitamin D2 metabolism occurs with lower efficiency than that observed for both cholesterol and D3 metabolism by P450scc | Bos taurus |